We evaluated the outcome of pregnancies followed between
1990 and 2000 in 93 women with type 1 diabetes, treated with
conventional intensive insulin therapy (n=68) or continuous
subcutaneous insulin infusion (n=25). We evaluated metabolic
control (fasting and 1-hour post-prandial plasma glucose and
HbA1c levels), spontaneous or induced abortions, time and mode
of delivery, maternal outcome (pregnancy-induced hypertension,
preeclampsia, placental insufficiency, hydramnios, hypoglycemic
coma, ketoacidosis) and fetal outcome (weight, hypoglycemia,
hypocalcemia, hyperbilirubinemia, fetal distress, asphyxia,
hyaline membrane disease, polycythemia, shoulder dystocia,
malformations). Patients treated with insulin pump more
frequently had background retinopathy and clinical neuropathy.
No significant differences were observed between the two groups
in metabolic control and maternal outcome. Glycemic control,
non-optimal in the prepregnancy state, improved significantly
during pregnancy, as shown by the progressive reduction in HbA1c
levels. As regards fetal outcome, no differences were observed
between the two groups in morbidity and especially in
malformation rate. Patients with malformed babies did not have
optimal metabolic control at conception. Thus, maternal and
perinatal outcomes were comparable in patients treated with
insulin pump and continuous subcutaneous insulin therapy, and
depended on metabolic control. In patients in higher White

s
class and with more unstable glycemia, we achieved metabolic
control and outcomes comparable with those of women of lower
White

s class and more stable glycemic values using the insulin
pump. Our data suggest that insulin pump therapy is useful in
problematic, complicated cases of women who want a baby.
Key words
Diabetes - Pregnancy - Insulin therapy - Maternal outcome - Fetal malformations