1 The effect of pre-dosing with 15 mg domperidone, a relatively selective dopamine 2-receptor antagonist, on the ocular hypotensive
action of a single oral dose of 25 μg pergolide, a dopamine 2-receptor agonist, was studied in 9 normal human volunteers,
using a non-invasive method.
2 Compared with domperidone followed after 1 h by placebo, placebo followed after 1 h by pergolide had an ocular hypotensive
effect in both eyes. Domperidone followed after 1 h by pergolide had no effect on intraocular pressure in both eyes.
2 The results of this study showed that domperidone inhibited the ocular hypotensive action of pergolide, suggesting that
pergolide reduces introcular pressure by the stimulation of the peripheral dopamine 2-receptors.
Key words domperidone - pergolide - dopaminergic agonists - intraocular pressure - non-contact tonometer - drug interaction