Some biochemical mechanisms of the protective effect of cordarone against cardiotoxic activity of strophanthin K are studied
in a rat model of circulation insufficiency. The potassium channel blocker and the cardiac glycoside are found to have opposite
effects on the lysosome apparatus of the heart.
Key Words
strophanthin K
-
cathepsin D
-
circulation insufficiency
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 407–409, October, 1996