Correction with cordarone of changes in cathepsin D activity induced by modeled circulation insufficiency and toxic action of strophanthin K

P. A. Galenko-Yaroshevskii, S. M. Lernkina and Ya. V. Kostin

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Abstract

Some biochemical mechanisms of the protective effect of cordarone against cardiotoxic activity of strophanthin K are studied in a rat model of circulation insufficiency. The potassium channel blocker and the cardiac glycoside are found to have opposite effects on the lysosome apparatus of the heart.

Key Words   strophanthin K  -  cathepsin D  -  circulation insufficiency

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 10, pp. 407–409, October, 1996

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