It has been established that relict fungi
Penicillium variabile Sopp can synthesize clavine alkaloids, rugulovasines A and B, which are revealed in this species for the first time. Submerged
cultivation of the strain-producer revealed several microcycles of conidia formation. The synthesis of alkaloids was also
of a cyclic character. The synchronism of cyclic rugulovasine biosynthesis and conidia formation was revealed. Zinc ions stimulated
fungal growth but had a negative effect on the biosynthesis of rugulovasines.
Key words filamentous fungi - permafrost ancient deposits -
Penicillium
- microcycle conidiation - biosynthesis - secondary metabolites - clavine alkaloids - rugulovasines
Original Russian Text © V.P. Zhelifonova, T.V. Antipova, S.M. Ozerskaya, N.E. Ivanushkina, A.G. Kozlovskii, 2006, published
in Mikrobiologiya, 2006, Vol. 75, No. 6, pp. 742–746.