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A Distributed Spatio-temporal EEG/MEG Inverse Solver
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A Distributed Spatio-temporal EEG/MEG Inverse Solver
Wanmei Ou1 , Polina Golland1 and Matti Hämäläinen2
| (1) |
Computer Science and Artificial Intelligence Laboratory, MIT, , USA |
| (2) |
Athinoula A. Martinos Center for Biomedical Imaging, MGH, , USA |
Abstract
We propose a novel ℓ1ℓ2-norm inverse solver for estimating the sources of EEG/MEG signals. Based on the standard ℓ1-norm inverse solver, the proposed sparse distributed inverse solver integrates the ℓ1-norm spatial model with a temporal model of the source signals in order to avoid unstable activation patterns and “spiky”
reconstructed signals often produced by the original solvers. The joint spatio-temporal model leads to a cost function with
an ℓ1ℓ2-norm regularizer whose minimization can be reduced to a convex second-order cone programming problem and efficiently solved
using the interior-point method. Validation with simulated and real MEG data shows that the proposed solver yields source
time course estimates qualitatively similar to those obtained through dipole fitting, but without the need to specify the
number of dipole sources in advance. Furthermore, the ℓ1ℓ2-norm solver achieves fewer false positives and a better representation of the source locations than the conventional ℓ2 minimum-norm estimates.
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