Real-time post processing for digital cinema is an extremely challenging task, due to large resolutions and the resulting high data rates. Applications with these requirements are beyond the scope of standard DSP processors, and ASICs are not economically viable due to a small market volume. As an answer to these challenges, the MORPHEUS platform offers reconfigurable processing engines with mixed granularity and an integrated toolset for rapid application development. This chapter presents a sophisticated film grain noise reduction algorithm and its mapping to the MORPHEUS platform.