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KATP channel polymorphism is associated with left ventricular size in hypertensive individuals: a large-scale community-based study
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Short Report
K ATP channel polymorphism is associated with left ventricular size in hypertensive individuals: a large-scale community-based
study
Santiago Reyes1, 2, Andre Terzic1, 2, 3, Douglas W. Mahoney4, Margaret M. Redfield1, Richard J. Rodeheffer1 and Timothy M. Olson1, 2, 3, 5 
| (1) |
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic, Rochester, MN, USA |
| (2) |
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA |
| (3) |
Department of Medical Genetics, Mayo Clinic, Rochester, MN, USA |
| (4) |
Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA |
| (5) |
Division of Pediatric Cardiology, Department of Pediatric and Adolescent Medicine, Mayo Clinic, Stabile 5, 200 First Street SW, Rochester, MN 55905, USA |
Received: 14 April 2008 Accepted: 19 May 2008 Published online: 27 May 2008
Abstract ATP-sensitive K + (K ATP) channel mutations have been identified in individuals with dilated cardiomyopathy and overt heart failure. Here, a common
E23K functional polymorphism in the Kir6.2 channel pore versus cardiac phenotype was studied in a cross-sectional community-based
cohort ( n = 2,031). The KK genotype was associated with greater left ventricular size among subjects with increased stress load due
to hypertension. These findings implicate Kir6.2 K23 as a risk factor for adverse subclinical myocardial remodeling, and underscore
the significance of cardiac K ATP channels within the population.
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