The synthesis of racemates of the 2α-methyl, 4-methyl, 17α-methyl, and 2α, 17α-dimethyl derivatives of 19-nor-D-homotestosterone has been described. Biological tests have shown that the introduction of a CH₃ group into positions 2α and 17α totally suppresses both androgenic and anabolic activity. The introduction of a CH₃ group into position 4 leads to a divergence of the anabolic and androgenic effects.