This chapter addresses three goals. The first is to explain the concept of geriatric syndromes. The second goal is to provide guidance so that geriatric syndromes can be anticipated and recognized in oncology practice. The third is to offer suggestions for managing and preventing selected geriatric complications of cancer treatment. As such, this chapter is not intended to be a pocket guide to geriatrics. It is intended to raise awareness of geriatric syndromes to trigger appropriate geriatric referral as an adjunct to cancer treatment.