Even though healthcare information systems have been introduced as a viable solution for reducing adverse drug events or medical errors, the current adoption rate is low and impact of system on patient safety and quality of care is not established well. To solve this problem, a new research framework with interdisciplinary approaches is suggested. The framework is based on two major characteristics of a healthcare IT system: effectiveness and efficiency. The former connects to patient safety and quality of care, and the latter is related with resources and design of the system. The framework is mainly grounded in human factors engineering, and includes psychology, systems and safety engineering, and an information systems approach.