In order to design computing machines able to self-repair and self-replicate, we have borrowed from nature two major mechanisms which are embedded in silicon: cell division and cell differentiation. Based on the so-called Tom Thumb algorithm, cellular division leads to a novel self-replicating loop endowed with universal construction. The self-replication of the totipotent cell of the “LSL” acronym serves as an artificial cell division example of the loop and results in the growth and differentiation of a multicellular organism.