Energetic particle observations in the interplanetary medium provide fundamental information about the origin, development and structure of coronal mass ejections. This paper reviews the status of our understanding of the ways in which particles are energised at the Sun in association with CMEs. This understanding will remain incomplete until the relationship between CMEs and flares is determined and we know the topology of the associated magnetic fields. The paper also discusses the characteristics of interplanetary CMEs that may be probed using particle observations.