Volume 49, Number 4, 318-320, DOI: 10.1007/s10384-004-0205-5

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Japanese Ophthalmological Society

Infantile Case of Occlusive Microvascular Retinopathy After Bone Marrow Transplantation

Eriko Kawase, Noriyuki Azuma, Yoko Shioda and Masaaki Kumagai

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Abstract

Background  

A variety of anterior and posterior segment ocular complications following bone marrow transplantation (BMT) have been well documented in adults and children, but retinal complications after BMT in infants have rarely been reported.

Case  

A 6-month-old male infant developed occlusive microvascular retinopathy after BMT to treat acute lymphocytic leukemia.

Observations  

Four months after the transplantation, retinal edema, hemorrhage, soft exudates, and neovascularization were found in the posterior pole fundus of the right eye and in the peripheral fundus of the left eye. After oral prednisolone was administered, the retinal lesions regressed and cicatrices with chorioretinal atrophy and fibrous tissue formed.

Conclusions  

Neovascularization following occlusive microvascular retinopathy after BMT in infant eyes responds well to oral prednisolone. The visual prognosis depends on the foveal involvement of the retinopathy. Jpn J Ophthalmol 2005;49:318–320 © Japanese Ophthalmological Society 2005

Key words  bone marrow transplantation - graft-versus-host disease - infant - occlusive microvascular retinopathy

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