The Third American Association of Pharmaceutical Scientists/Food and Drug Administration Bioanalytical Workshop, held in 2006,
reviewed and evaluated current practices and proposed that carryover and contamination be assessed not only during the validation
of an assay but also during the application of the method in a study. In this article, the potential risks of carryover and
contamination in each stage of a bioanalytical method are discussed, to explain to the industry why this recommendation is
being made.
Keywords Carryover - contamination - extraction - chromatography - detection - bioanalysis - accuracy - precision - memory effect
Published: November 2, 2007