Volume 143, Number 2, 152-153, DOI: 10.1007/BF00445806

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Avascular necrosis of bone in neuroblastoma treated with combination chemotherapy

Eiichi Ishii, Nobuyuki Yoshida and Sumio Miyazaki

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Abstract

We treated two children with neuroblastoma and during the course of chemotherapy, avascular necrosis of the femoral head occurred. The main pathogenetic factor of this necrosis may be the toxic effect of cyclophosphamide.

Key words  Avascular necrosis - Neuroblastoma - Cyclophosphamide

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