The environment onboard a ship presents a typical example of a severe environment, displaying extreme conditions of temperature and relative humidity, especially in the engine room. Datasheets, the international labour organization, and standards do not provide clear information about the suitable ambience of the engine room, its design conditions, and the role of marine engineers in preventing work-related risk. In this study, air temperature and relative humidity were monitored at several locations onboard a merchant ship. These real monitored data were then compared with the ISO design indications to obtain an effective work risk analysis. From these indoor temperature and relative humidity data, the corresponding parameters of thermal comfort in the engine control room and the heat stress and sweating index of a worker in the engine room were determined. As a function of these indices, the maximum time that a worker can stay in the engine room and the time for which he must rest in the control room were also calculated in the present study. Some design corrections are also proposed herein to improve these environments.