This paper highlights key topic areas to be discussed the authors in a panel format during the Augmented Cognition thematic area paper session: “Augmented Cognition Lessons Learned and Future Directions for Enabling ‘Anyone, Anytime, Anywhere’ Applications”. The term “killer app” has been part of the vernacular in the commercial computer software and electronic devices industry to refer to breakthrough technologies [2]. A “killer app” generally emerges with the development of related technologies that extends over some time and involves numerous variations on a basic concept. Hypotheses may be offered with respect to the conditions that will be needed to enable a similar situation with augmented cognition technologies. This paper and resulting panel session will address the numerous concepts that have emerged from the augmented cognition field to date and postulate how and when this field’s first “killer app” may emerge (e.g., 5, 10, 15, or more years from now).