This paper focuses on the acculturation model of second-culture-acquisition for Latino immigrants. Two theoretical frameworks, assimilation and alternation theories, are compared within the acculturation model. Empirical research findings suggest that assimilation is a risk factor for increases in negative health behaviors and mental health problems. Conversely, biculturalism appears to be an emerging protective factor that buffers assimilation stress, enhances socio-cognitive functioning, and increases academic achievement. A review of bicultural skills training interventions shows these programs are effective in decreasing the risk for problematic behavior. Finally, a refined model of bicultural skills training for Latino immigrant families is proposed based on the acculturation research literature and extensive interviews with Latino families in North Carolina.