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Deformation Based Morphometry Analysis of Serial Magnetic Resonance Images of Mouse Brains
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Deformation Based Morphometry Analysis of Serial Magnetic Resonance Images of Mouse Brains
Satheesh Maheswaran1  , Hervé Barjat4, Simon Bate4, Thomas Hartkens3, Derek L. G. Hill3, Michael F. James4, Lorna Tilling4, Neil Upton4, Jo Hajnal2 and Daniel Rueckert1
| (1) |
Dept. of Computing, 180 Queen’s Gate, South Kensington Campus, Imperial College, London, SW7 2AZ, |
| (2) |
Imaging Sciences Department, Imperial College, Hammersmith Hospital, London, W12 0NN, |
| (3) |
IXICO Ltd, London, NW1 0NH, |
| (4) |
Neurology and GI Center of Excellence for Drug Discovery, GlaxoSmithKline, Harlow, Essex, CM19 5AW, |
Abstract
Deformation based morphometry is used to detect differences in in-vivo Magnetic Resonance Image (MRI) of the mouse brain obtained
from two transgenic strains: TASTPM mice that over-express proteins associated with Alzheimer’s disease, and wild-type mice.
MRI was carried out at four time points. We compare two different methods to detect group differences in the longitudinal
and cross-sectional data. Both methods are based on non-rigid registration of the images to a mouse brain atlas. The whole
brain volume measurements on 27 TASTPM and wild-type animals are reproducible to within 0.4% of whole brain volume. The agreement
between different methods for measuring volumes in a serial study is shown. The ability to quantify changes in growth between
strains in whole brain, hippocampus and cerebral cortex is demonstrated.
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