For the effective alignment of ontologies, the computation of equivalence relations between elements of ontologies is not enough: Subsumption relations play a crucial role as well. In this paper we propose the "Classification-Based Learning of Subsumption Relations for the Alignment of Ontologies" (CSR) method. Given a pair of concepts from two ontologies, the objective of CSR is to identify patterns of concepts’ features that provide evidence for the subsumption relation among them. This is achieved by means of a classification task, using state of the art supervised machine learning methods. The paper describes thoroughly the method, provides experimental results over an extended version of benchmarking series and discusses the potential of the method.