The Canadian Centre for Climate Modelling and Analysis (CCCma) second generation climate model (GCMII) consists of an atmospheric GCM coupled to mixed layer ocean. It is used to investigate the climate response to a doubling of the CO₂ concentration together with the direct effect of scattering by sulphate aerosols. As expected, the aerosols offset some of the greenhouse gas (GHG) warming; the global annual mean screen temperature change due to doubled CO₂ is 3.4 °C in this model and this is reduced to 2.7 °C when an estimate of the direct effect of anthropogenic sulphate aerosols is included. The pattern of climate response to the comparatively localized aerosol forcing is not itself localized, and it bears a striking resemblance to the response pattern that arises from the globally distributed change in GHG forcing. This “non-local” response to “localized” forcing indicates that the pattern of climate response is determined, to first order, by the overall magnitude of the change in forcing rather than its detailed nature or structure. Feedback processes operating in the system apparently determine this pattern by locally amplifying and suppressing the response to the magnitude of the change in forcing. The influence of the location of the change in forcing is relatively small. These “non-local” and “local” effects of aerosol forcing are characterized and displayed and some of their consequences discussed. Effects on the moisture budget and on the energetics of the global climate are also examined.