The practice of speculation in resolving data dependences based on value prediction has been studied as a means of extracting more instruction level parallelism. There are many studies on value prediction mechanisms with high predictabilities. However, to the best of our knowledge, the influence of compiler optimizations on value prediction has not been investigated. In this paper we evaluate efficiency of value prediction on several binaries which are compiled with different optimization levels. Detailed simulations reveal that value prediction is still effective for highly optimized binaries.